Systems and methods for internal combustion engine operation with exhaust gas recirculation and turbocharging are disclosed. The systems include an exhaust gas recirculation loop for recirculating exhaust gas flow from a first portion of the cylinders of the engine into an intake system prior to combustion. The system further includes a turbine with first and second inlets for receiving exhaust gas flows from respective first and second parts of the exhaust gas of the remaining portion of the cylinders.