The subject matter described herein includes systems, methods, and computer readable media for encrypting Diameter identification information contained in Diameter signaling messages. The system includes a Diameter agent that comprises a network interface configured to receive, from a first Diameter node, a Diameter signaling message that includes Diameter identification information associated with the first Diameter node and a Diameter encryption topology hiding module (ETHM) configured to encrypt the Diameter identification information to generate encrypted Diameter identification information and to replace the Diameter identification information in the Diameter signaling message with the encrypted Diameter identification information. The Diameter agent further includes a routing module configured to route the Diameter signaling message with the encrypted Diameter identification information to a second Diameter node.