Invention Grant
US09255106B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors
有权
取代的[1,2,4]三唑并[4,3-a]吡嗪作为PARP-1抑制剂
![Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors](/docs/US/2016-02-09/US09255106B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors
- Patent Title (中): 取代的[1,2,4]三唑并[4,3-a]吡嗪作为PARP-1抑制剂
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Application No.: US14418705Application Date: 2013-07-24
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Publication No.: US09255106B2Publication Date: 2016-02-09
- Inventor: Ao Zhang , Zehong Miao , Na Ye , Xiajuan Huan , Zilan Song , Chuanhuizi Chen , Yi Chen , Jian Ding
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee Address: CN Shanghai
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: CN201210272101 20120801
- International Application: PCT/CN2013/079998 WO 20130724
- International Announcement: WO2014/019468 WO 20140206
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D241/38 ; C07D487/04 ; A61K31/501 ; A61K31/502
![Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors](/abs-image/US/2016/02/09/US09255106B2/abs.jpg.150x150.jpg)
Abstract:
Provided is a piperazinotriazole compound represented by general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer or hydrate thereof. Also provided are a pharmaceutical composition comprising the compound, a method for preparing the compound and a method of use thereof as a high-selectivity poly(adenosine diphosphate-ribose)polymerase-1 (PARP-1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
Public/Granted literature
- US20150166544A1 PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN DRUG PREPARATION Public/Granted day:2015-06-18
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