A chip stacking packaging structure is provided for achieving high-density stacking and improving a heat dissipation efficiency of the chip stacking packaging structure. The chip stacking packaging structure includes a main substrate and at least one stacking substrate in which a main chip is disposed in the main substrate, at least one stacking chip is disposed on the stacking substrate, and a side edge of the stacking substrate is disposed on the main substrate, so that the stacking chip is connected to the main chip.