A method and apparatus of feeding back channel state information in a multi-node system are provided. The method includes receiving a reference signal of N nodes, wherein N is a natural number equal to or more than 2, aligning the N nodes in an order of preferring the N nodes based on a result of measuring the reference signal, generating channel state information for the aligned nodes, and transmitting the generated channel state information to the base station, wherein the channel state information is generated with respect to N node combinations configured from the aligned nodes, and wherein the N node combinations are obtained by adding next highest-priority nodes to a first node combination one by one, the first node combination consisting a highest-priority node among the aligned nodes.