A method and an apparatus for transmitting and receiving an uplink signal by a mobile terminal in a wireless communication system are provided. The first mobile terminal includes a receiver configured to receive, from a base station, a power control variable determined based on an interference value for a first receive beam used in order to receive an uplink signal of the first mobile terminal from among a plurality of receive beams of the base station, to receive, from the base station, neighboring receive beam allocation data indicating whether any of the receive beams in the plurality of receive beams, different from the first receive beam, is being used for uplink signal reception, to determine an uplink transmit power value based on the received power control variable and neighboring receive beam allocation data, and to transmit an uplink signal to the base station by using the determined uplink transmit power value.