发明授权
- 专利标题: Dihydroquinoline-2-one derivatives
- 专利标题(中): 二氢喹啉-2-酮衍生物
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申请号: US13612956申请日: 2012-09-13
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公开(公告)号: US09260408B2公开(公告)日: 2016-02-16
- 发明人: Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Henner Knust , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan , Mingwei Zhou
- 申请人: Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Henner Knust , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan , Mingwei Zhou
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 优先权: WOPCT/CN2011/079673 20110915
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D471/06 ; C07D487/10 ; C07F7/18 ; A61P13/12 ; A61P9/04 ; A61P9/12
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
公开/授权文献
- US20130072679A1 DIHYDROQUINOLINE-2-ONE DERIVATIVES 公开/授权日:2013-03-21
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