The present subject matter discloses a method for antenna activity detection in multi-antenna communication devices. In one embodiment, the method comprises computing a received signal strength indicator (RSSI) value for each of a plurality of antennas based on a sampled data associated with each of the antennas. The RSSI values may then be analyzed to identify an antenna having a highest RSSI value as a primary antenna and one or more antennas having the RSSI value less than the highest RSSI value as auxiliary antennas. Further, an RSSI difference for each of the auxiliary antennas is calculated and compared with a first threshold value to ascertain one or more potentially inactive antennas from among the auxiliary antennas. The potentially inactive antennas may then be further analyzed to identify one or more inactive antennas based at least in part on the RSSI value.