Invention Grant
US09265835B2 Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative
有权
罗替戈汀或其衍生物或罗替戈汀或其衍生物的药学上可接受的盐的组合物
- Patent Title: Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative
- Patent Title (中): 罗替戈汀或其衍生物或罗替戈汀或其衍生物的药学上可接受的盐的组合物
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Application No.: US13989550Application Date: 2011-11-25
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Publication No.: US09265835B2Publication Date: 2016-02-23
- Inventor: Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
- Applicant: Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
- Applicant Address: CN Shandong
- Assignee: SHAN DONG LUYE PHARMACEUTICAL CO., LTD.
- Current Assignee: SHAN DONG LUYE PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Shandong
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Priority: CN201010576447 20101125
- International Application: PCT/CN2011/001958 WO 20111125
- International Announcement: WO2012/068783 WO 20120531
- Main IPC: A61K9/50
- IPC: A61K9/50 ; A61K31/38 ; C07D333/20 ; A61K47/34 ; A61K9/16 ; A61K31/381
Abstract:
The disclosure relates to a composition comprising rotigotine or a pharmaceutically acceptable salt thereof; at least one poly(lactide-co-glycolide) (PLGA); and at least one fatty acid, wherein the at least one fatty acid is at least 0.5% in weight relative to the total weight of the composition. The composition as disclosed herein has significantly reduced burse release effect. The disclosure also provides a method of treating Parkinson's disease comprising administering an effective amount of the composition as disclosed to a subject in need thereof.
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