发明授权
- 专利标题： Methods of modulating MicroRNAs in the treatment of pulmonary arterial hypertension
- 专利标题（中）： 调节微小RNA治疗肺动脉高压的方法
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申请号： US14116724申请日： 2012-05-09
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公开(公告)号： US09267134B2公开(公告)日： 2016-02-23
- 发明人: Andrew Baker , Margaret MacLean , Nicholas Morrell
- 申请人： Andrew Baker , Margaret MacLean , Nicholas Morrell
- 申请人地址： GB Glasgow GB Cambridge
- 专利权人： The University Court of the University of Glasgow,Cambridge Enterprise Limited
- 当前专利权人： The University Court of the University of Glasgow,Cambridge Enterprise Limited
- 当前专利权人地址： GB Glasgow GB Cambridge
- 代理机构： Cooley LLP
- 国际申请： PCT/GB2012/051018 WO 20120509
- 国际公布： WO2012/153135 WO 20121115
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/113
摘要：
The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.
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