A method of multi-set RRC signaling for ap-SRS configuration is provided to enhance ap-SRS flexibility. An eNB transmits a plurality of sets of UE-specific SRS parameters to a UE via upper layer messaging in a multi-carrier wireless communication system. The eNB also determines triggering information of a selected set of UE-specific SRS parameters and an indicated carrier for the UE. The eNB then transmits an uplink or downlink grant over a primary carrier, the grant comprises triggering information for the UE to send an ap-SRS over the indicated carrier using the selected set of UE-specific SRS parameters. In one embodiment of joint signaling, the plurality of sets of UE-specific SRS parameters are signaled together in a single RRC transmission. In another embodiment of separate signaling, each set of UE-specific SRS parameters is signaled independently.