Invention Grant
- Patent Title: Prodrugs of 1,4-benzodiazepinone compounds
- Patent Title (中): 1,4-苯并二氮杂酮化合物的前药
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Application No.: US14429930Application Date: 2013-09-20
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Publication No.: US09273075B2Publication Date: 2016-03-01
- Inventor: Ashvinikumar V. Gavai , Wen-Ching Han , Brian E. Fink , Victor R. Guarino
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060832 WO 20130920
- International Announcement: WO2014/047391 WO 20140327
- Main IPC: C07D243/18
- IPC: C07D243/18 ; C07D243/26 ; C07F9/645 ; A61K31/675 ; C07D243/24 ; A61K31/5513 ; C07D401/12 ; A61K45/06
Abstract:
Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry; or b) R1 is Rx and R2 is H; wherein Rx and Ry are disclosed herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are prodrugs of compounds that are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20150232491A1 PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS Public/Granted day:2015-08-20
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