Invention Grant
US09273140B2 Antibody for detecting DNA damage in cells utilizing cell membrane surface antigen Ly6D
有权
用细胞膜表面抗原Ly6D检测细胞DNA损伤的抗体
- Patent Title: Antibody for detecting DNA damage in cells utilizing cell membrane surface antigen Ly6D
- Patent Title (中): 用细胞膜表面抗原Ly6D检测细胞DNA损伤的抗体
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Application No.: US13891652Application Date: 2013-05-10
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Publication No.: US09273140B2Publication Date: 2016-03-01
- Inventor: Yoshikazu Kurosawa , Maiko Kurosawa , Gene Kurosawa
- Applicant: FUJITA HEALTH UNIVERSITY , PERSEUS PROTEOMICS INC.
- Applicant Address: JP Toyoake-shi, Aichi JP Tokyo
- Assignee: FUJITA HEALTH UNIVERSITY,Perseus Proteomics Inc.
- Current Assignee: FUJITA HEALTH UNIVERSITY,Perseus Proteomics Inc.
- Current Assignee Address: JP Toyoake-shi, Aichi JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C12N15/13 ; C12N15/85 ; G01N33/68 ; C07K16/28
Abstract:
To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.
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