发明授权
- 专利标题： Method for producing fine particles of aripiprazole anhydride crystals B
- 专利标题（中）： 制备阿立哌唑酐晶体微粒的方法B
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申请号： US14128305申请日： 2012-06-29
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公开(公告)号： US09278934B2公开(公告)日： 2016-03-08
- 发明人: Takuji Bando , Katsuhiko Yano , Makoto Fukana , Satoshi Aoki
- 申请人： Takuji Bando , Katsuhiko Yano , Makoto Fukana , Satoshi Aoki
- 申请人地址： JP Tokyo
- 专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 国际申请： PCT/JP2012/067258 WO 20120629
- 国际公布： WO2013/002420 WO 20130103
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D403/02 ; C07D215/22
摘要：
The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.
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