Systems and methods for radio frequency digital predistortion in a multi-band transmitter are disclosed. In one embodiment, the multi-band transmitter includes a digital upconversion system configured to digitally upconvert digital input signals to provide digital radio frequency signals. Each digital input signal and thus each digital radio frequency signal corresponds to a different band of a multi-band transmit signal to be transmitted by the multi-band transmitter. The multi-band transmitter also includes a radio frequency digital predistortion system configured to digitally predistort the digital radio frequency signals to provide predistorted digital radio frequency signals, and a combiner configured to combine the predistorted digital radio frequency signals to provide a multi-band predistorted digital radio frequency signal.