According to one embodiment, a paper sheet handling apparatus includes a supply unit including a support surface which tilts from a vertical direction, and a mounting surface substantially perpendicular to the support surface, and configured to receive a plurality of paper sheets which tilt along the support surface and are stacked on the mounting surface, a pick up mechanism configured to pick up the paper sheets from a mounting surface side of the supply unit, a conveyance path configured to convey the picked up paper sheet, an inspection device configured to inspect the conveyed paper sheet, and an accumulation unit configured to accumulate the inspected paper sheets.