发明授权
![Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors](/docs/US/2016-03-15/US09284317B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors
- 专利标题（中）： 取代的咪唑并[1,2-a]吡嗪作为MPS-1抑制剂
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申请号： US13994335申请日： 2011-12-13
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公开(公告)号： US09284317B2公开(公告)日： 2016-03-15
- 发明人: Marcus Koppitz , Ulrich Klar , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister
- 申请人： Marcus Koppitz , Ulrich Klar , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister
- 申请人地址： DE Monheim
- 专利权人： Bayer Intellectual Property GmbH
- 当前专利权人： Bayer Intellectual Property GmbH
- 当前专利权人地址： DE Monheim
- 优先权： EP10195692 20101217
- 国际申请： PCT/EP2011/072589 WO 20111213
- 国际公布： WO2012/080234 WO 20120621
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D241/36 ; C07D487/04 ; C07D403/02
![Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors](/abs-image/US/2016/03/15/US09284317B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to substituted imidazopyrazine compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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