Provided is an interference cancellation method by a User Equipment (UE) in a cellular communication system. The method includes receiving a signal including a desired signal and an interference signal from at least one base station; determining a universal constellation diagram based on at least one of a transmission parameter of the desired signal and a transmission parameter of the interference signal; blindly detecting an additional transmission parameter of the interference signal using the determined universal constellation diagram; and cancelling the interference signal from the received signal using the detected additional transmission parameter.