发明授权
- 专利标题： Quinolines and aza-quinolines as CRTH2 receptor modulators
- 专利标题（中）： 喹啉和氮杂喹啉作为CRTH2受体调节剂
-
申请号： US13996371申请日： 2011-12-19
-
公开(公告)号： US09290453B2公开(公告)日： 2016-03-22
- 发明人: Christopher W. Boyce , Salem Fevrier , Kevin D. McCormick , Anandan Palani , Robert G. Aslanian , Phieng Siliphaivanh , Joey L. Methot , William Colby Brown , Henry Vaccaro
- 申请人： Christopher W. Boyce , Salem Fevrier , Kevin D. McCormick , Anandan Palani , Robert G. Aslanian , Phieng Siliphaivanh , Joey L. Methot , William Colby Brown , Henry Vaccaro
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Eric A. Meade; Catherine D. Fitch
- 国际申请： PCT/US2011/065730 WO 20111219
- 国际公布： WO2012/087872 WO 20120628
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/4709 ; A61K31/496 ; A61K31/4375 ; C07D215/48 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D471/04 ; C07D491/107 ; C07D405/12 ; A61K45/06
摘要：
The invention provides certain quinolines and aza-quinolines of the Formula (I), and their pharmaceutically acceptable salts, wherein E, J1, Ja, Jb, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
公开/授权文献
信息查询
