发明授权
US09290535B2 Uridine-based gadolinium complex and MRI contrast agent including the same
有权
基于尿苷的钆络合物和MRI造影剂包括相同
- 专利标题： Uridine-based gadolinium complex and MRI contrast agent including the same
- 专利标题（中）： 基于尿苷的钆络合物和MRI造影剂包括相同
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申请号： US14004831申请日： 2012-03-15
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公开(公告)号： US09290535B2公开(公告)日： 2016-03-22
- 发明人: Jong-Seung Kim , Sankarprasad Bhuniya , Sumin Lee , Kwan Soo Hong , Hyunseung Lee , Hyeyoung Moon
- 申请人： Jong-Seung Kim , Sankarprasad Bhuniya , Sumin Lee , Kwan Soo Hong , Hyunseung Lee , Hyeyoung Moon
- 申请人地址： KR Seoul KR Daejeon
- 专利权人： Korea University Researchand Business Foundation,Korea Basic Science Institute
- 当前专利权人： Korea University Researchand Business Foundation,Korea Basic Science Institute
- 当前专利权人地址： KR Seoul KR Daejeon
- 代理机构： Alston & Bird LLP
- 优先权： KR10-2011-0024292 20110318
- 国际申请： PCT/KR2012/001864 WO 20120315
- 国际公布： WO2012/128504 WO 20120927
- 主分类号： C07F5/00
- IPC分类号： C07F5/00 ; C07H23/00 ; A61K49/10 ; C07H19/067
摘要：
The present invention relates to a new uridine nucleoside-based amphiphilic gadolinium complex and a magnetic resonance imaging (MRI) contrast agent including the gadolinium complex. The MRI contrast agent has high relaxivity, high binding affinity for and stability in human serum albumin, pH response, and high liver specificity.