The present invention relates to a method and an apparatus for controlling uplink transmission power of a user equipment. In the method, a serving base station receives from the user equipment a signal measurement report for a first neighboring base station transmitting the strongest signal to the user equipment, transmits, to the user equipment, a control signal including a path loss information for calculating the uplink transmission power, transmits, to the user equipment and the first neighboring base station scheduling information for the user equipment and receives, from the first neighboring base station, an uplink signal of the user equipment. According to the method, the uplink transmission power can be adjusted based on a pico base station close to the user equipment when the macro base station is a serving base station such that the amount of interference power of a multi cell may be minimized.