发明授权
US09295734B2 Branched amphipathic block polymer and molecular aggregate and drug delivery system using same
有权
支链两亲嵌段聚合物和分子骨料和药物递送系统使用相同
- 专利标题: Branched amphipathic block polymer and molecular aggregate and drug delivery system using same
- 专利标题(中): 支链两亲嵌段聚合物和分子骨料和药物递送系统使用相同
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申请号: US14126803申请日: 2012-06-22
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公开(公告)号: US09295734B2公开(公告)日: 2016-03-29
- 发明人: Eiichi Ozeki , Shunsaku Kimura , Akira Makino
- 申请人: Eiichi Ozeki , Shunsaku Kimura , Akira Makino
- 申请人地址: JP Kyoto JP Kyoto
- 专利权人: SHIMADZU CORPORATION,KYOTO UNIVERSITY
- 当前专利权人: SHIMADZU CORPORATION,KYOTO UNIVERSITY
- 当前专利权人地址: JP Kyoto JP Kyoto
- 代理机构: Cheng Law Group, PLLC
- 优先权: JP2011-139468 20110623
- 国际申请: PCT/JP2012/066023 WO 20120622
- 国际公布: WO2012/176885 WO 20121227
- 主分类号: A61K8/00
- IPC分类号: A61K8/00 ; A61K49/00 ; A61K9/107 ; B82Y40/00 ; A61K47/34 ; A61K9/51 ; C08L101/00 ; A61K49/12 ; A61K47/48 ; C08G83/00
摘要:
Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.
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