A pickup mechanism includes a mechanical frame, at least one pickup roller, a paper pressing board disposed above the mechanical frame, a transmitting element, a cover covered on the paper pressing board, at least one stopper element pivotally mounted to the paper pressing board, and at least one elastic element elastically disposed between the cover and the paper pressing board. The pickup roller is disposed under the mechanical frame. The paper pressing board has a bottom board. A top of the bottom board protrudes upward to form a movable portion. A front of the movable portion defines a driven link. The transmitting element is cooperated with the driven link of the paper pressing board to bring along the paper pressing board to be pressed downward and be raised up. The cover has a top wall. A bottom of the top wall protrudes downward to form a locking part.