A driving apparatus of a display panel comprises a display panel for displaying an image according to an image signal; a DC-DC converter configured to output a voltage supplied from an external power source as a driving power source voltage for driving the display panel; a signal controller configured to generate a power supply enable signal for controlling an operation of the DC-DC converter and transfer it to the DC-DC converter; and a driving controller configured to determine an operation of the DC-DC converter according to a state of the driving power source voltage by receiving the driving power source voltage and comparing the received driving power source voltage with a pulse voltage of the power supply enable signal, and drive the DC-DC converter by adjusting the power supply enable signal in case the DC-DC converter is not operated.