A finger biometric sensing device may include drive circuitry capable of generating a drive signal and an array of finger biometric sensing pixel electrodes cooperating with the drive circuitry and capable of generating a detected signal based upon placement of a finger adjacent the array of finger biometric sensing pixel electrodes. The detected signal may include a relatively large drive signal component and a relatively small sense signal component superimposed thereon. The finger biometric sensing device may also include a gain stage coupled to the array of finger biometric sensing pixel electrodes, and drive signal nulling circuitry coupled to the gain stage capable of reducing the relatively large drive signal component from the detected signal.