Invention Grant
- Patent Title: Orally dispersible tablet containing compacted sildenafil base
- Patent Title (中): 口腔分散片含有压实的西地那非碱
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Application No.: US14452209Application Date: 2014-08-05
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Publication No.: US09301959B2Publication Date: 2016-04-05
- Inventor: Sven Winter , Max-Werner Scheiwe , Dieter Swatschek
- Applicant: RATIOPHARM GMBH
- Applicant Address: DE Ulm
- Assignee: ratiopharm GmbH
- Current Assignee: ratiopharm GmbH
- Current Assignee Address: DE Ulm
- Agency: Milstein Zhang & Wu LLC
- Main IPC: A61K31/519
- IPC: A61K31/519 ; A61K9/20 ; A61K9/00 ; A61K9/16

Abstract:
The invention relates to a process for the preparation of a pharmaceutical intermediate, comprising the steps of (i) mixing (a-i) sildenafil base, (b-i) wicking agent, (c-i) disintegrant, (d-i) optionally glidant; (ii) compacting the mixture; and (iii) milling the compacted material; and to an intermediate obtainable by that process. In addition, the invention relates to a process for the preparation of an orally dispersible tablet (hereinafter also referred to as an “orodispersible tablet”) comprising the intermediate of the invention, and to orodispersible tablets obtainable by that process.
Public/Granted literature
- US20140343072A1 ORALLY DISPERSIBLE TABLET CONTAINING COMPACTED SILDENAFIL BASE Public/Granted day:2014-11-20
Information query
IPC分类: