Invention Grant
- Patent Title: Fluorescent probe for imaging lymph nodes
- Patent Title (中): 用于成像淋巴结的荧光探针
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Application No.: US13700780Application Date: 2011-05-31
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Publication No.: US09302018B2Publication Date: 2016-04-05
- Inventor: Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
- Applicant: Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2010-124252 20100531
- International Application: PCT/JP2011/003069 WO 20110531
- International Announcement: WO2011/152046 WO 20111208
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C07D209/60 ; C09B23/08
Abstract:
Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
Public/Granted literature
- US20130129631A1 Fluorescent Probe for Imaging Lymph Nodes Public/Granted day:2013-05-23
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