发明授权
US09303035B2 Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel
有权
取代的吡嗪并[1'，2'：1,2]吡咯并[3,4-d]嘧啶，嘧啶并[4'，5'：3,4]吡咯并[2,1-c] [1,4] 嘧啶并[4'，5'：3,4]吡咯并[1,2-d] [1,4]氧氮杂用于抑制CFTR通道
![Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel](/docs/US/2016-04-05/US09303035B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel
- 专利标题（中）： 取代的吡嗪并[1'，2'：1,2]吡咯并[3,4-d]嘧啶，嘧啶并[4'，5'：3,4]吡咯并[2,1-c] [1,4] 嘧啶并[4'，5'：3,4]吡咯并[1,2-d] [1,4]氧氮杂用于抑制CFTR通道
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申请号： US14109927申请日： 2013-12-17
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公开(公告)号： US09303035B2公开(公告)日： 2016-04-05
- 发明人: Mahbub Ahmed , Alexander Ashall-Kelly , Graham Charles Bloomfield , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Sheperd , Paul Wright
- 申请人： Mahbub Ahmed , Alexander Ashall-Kelly , Graham Charles Bloomfield , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Sheperd , Paul Wright
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Jing Grace Sun
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D239/70 ; C07D487/14 ; A61K31/5383 ; A61K31/553 ; A61K45/06 ; C07D498/14
![Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel](/abs-image/US/2016/04/05/US09303035B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
公开/授权文献
- US20140171412A1 TRICYCLIC COMPOUNDS 公开/授权日：2014-06-19
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