发明授权
US09309250B2 Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
有权
取代的吡咯并[2,3-b]吡嗪作为ATR激酶抑制剂
![Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors](/docs/US/2016-04-12/US09309250B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
- 专利标题（中）： 取代的吡咯并[2,3-b]吡嗪作为ATR激酶抑制剂
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申请号： US13531467申请日： 2012-06-22
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公开(公告)号： US09309250B2公开(公告)日： 2016-04-12
- 发明人: Pierre-Henri Storck , Jean-Damien Charrier , Alistair Rutherford , Michael Paul Mortimore , Somhairle MacCormick , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant
- 申请人： Pierre-Henri Storck , Jean-Damien Charrier , Alistair Rutherford , Michael Paul Mortimore , Somhairle MacCormick , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D241/38 ; C07D487/04
![Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors](/abs-image/US/2016/04/12/US09309250B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US20130034616A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 公开/授权日：2013-02-07
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