Invention Grant
- Patent Title: Pyrrolopyrimidine compounds as inhibitors of CDK4/6
- Patent Title (中): 吡咯并嘧啶化合物作为CDK4 / 6的抑制剂
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Application No.: US14568410Application Date: 2014-12-12
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Publication No.: US09309252B2Publication Date: 2016-04-12
- Inventor: Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
- Applicant: Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Laura K. Madden
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/04 ; C07D519/00 ; C07D471/08 ; C07D471/10 ; C07D487/08 ; C07D498/08 ; C07D498/20 ; C07D487/10 ; C07D498/10
Abstract:
The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Public/Granted literature
- US20150099737A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 Public/Granted day:2015-04-09
Information query
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