Invention Grant
- Patent Title: Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
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Application No.: US13582401Application Date: 2011-03-01
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Publication No.: US09309324B2Publication Date: 2016-04-12
- Inventor: Zhuozhi Wang , Junliang Pan , Joanna Grudzinska , Christian Votsmeier , Jan Tebbe , Joerg Birkenfeld , Nina Wobst , Simone Brueckner , Susanne Steinig , Peter Scholz
- Applicant: Zhuozhi Wang , Junliang Pan , Joanna Grudzinska , Christian Votsmeier , Jan Tebbe , Joerg Birkenfeld , Nina Wobst , Simone Brueckner , Susanne Steinig , Peter Scholz
- Applicant Address: US NY Tarrytown
- Assignee: BAYER HEALTHCARE LLC
- Current Assignee: BAYER HEALTHCARE LLC
- Current Assignee Address: US NY Tarrytown
- Agency: VLP Law Group LLP
- Agent Kurt T. Mulville
- International Application: PCT/US2011/026766 WO 20110301
- International Announcement: WO2011/109452 WO 20110909
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/38 ; A61K39/00
Abstract:
Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
Public/Granted literature
- US20120329996A1 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI) Public/Granted day:2012-12-27
Information query
