A driver circuit for receiving a data input and generating an output signal according to at least the data input is provided. The driver circuit includes a pair of differential output terminals, a current mode drive unit and a voltage mode drive unit. The pair of differential output terminals has a first output terminal and a second output terminal. The current mode drive unit is arranged for outputting a first reference current from one of the first and second output terminals and receiving the first reference current from the other of the first and the second output terminals according to the first data input. The voltage mode drive unit is arranged for coupling a first reference voltage to one of the first and the second output terminals and coupling a second reference voltage to the other of the first and the second output terminals according to the first data input.