发明授权
US09314538B2 Nucleic acid molecules encoding antibody drug conjugates (ADC) that bind to 191P4D12 proteins
有权
编码与191P4D12蛋白结合的抗体药物偶联物（ADC）的核酸分子
- 专利标题： Nucleic acid molecules encoding antibody drug conjugates (ADC) that bind to 191P4D12 proteins
- 专利标题（中）： 编码与191P4D12蛋白结合的抗体药物偶联物（ADC）的核酸分子
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申请号： US14798302申请日： 2015-07-13
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公开(公告)号： US09314538B2公开(公告)日： 2016-04-19
- 发明人: Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
- 申请人： AGENSYS, INC. , Seattle Genetics, Inc.
- 申请人地址： US CA Santa Monica US WA Bothell
- 专利权人： AGENSYS, INC.,SEATTLE GENETICS, INC.
- 当前专利权人： AGENSYS, INC.,SEATTLE GENETICS, INC.
- 当前专利权人地址： US CA Santa Monica US WA Bothell
- 代理机构： Morrison & Foerster LLP
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C12P21/08 ; A61K47/48 ; C07K16/30 ; A61N5/10 ; A61K39/00
摘要：
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.