Invention Grant
US09315504B2 Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof
有权
制备4 - （（6BR，10AS）-3-甲基-2,3,6B，9,10,10A-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3 -de]喹喔啉-8-（7H） - 基）-1-（4-氟苯基）-1-丁酮或其药学上可接受的盐
![Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof](/docs/US/2016-04-19/US09315504B2/abs.jpg.600x600.jpg)
- Patent Title: Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof
- Patent Title (中): 制备4 - （（6BR，10AS）-3-甲基-2,3,6B，9,10,10A-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3 -de]喹喔啉-8-（7H） - 基）-1-（4-氟苯基）-1-丁酮或其药学上可接受的盐
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Application No.: US14323545Application Date: 2014-07-03
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Publication No.: US09315504B2Publication Date: 2016-04-19
- Inventor: John Charles Tomesch , Peng Li , Wei Yao , Qiang Zhang , James David Beard , Andrew S. Thompson , Hua Cheng , Lawrence P. Wennogle
- Applicant: INTRA-CELLULAR THERAPIES, INC.
- Applicant Address: US NY New York
- Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee Address: US NY New York
- Agency: Hoxie & Associates LLC
- Main IPC: C07D241/38
- IPC: C07D241/38 ; C07D471/16 ; C07D471/04
![Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof](/abs-image/US/2016/04/19/US09315504B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides methods for the preparation of 4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3′,4′:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone in free form or a salt thereof.
Public/Granted literature
- US20140364609A1 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS Public/Granted day:2014-12-11
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