A system and method includes reception of a mask x-ray image of a patient volume, reception of a plurality of sequential x-ray images of the patient volume including a contrast medium, subtraction of the mask x-ray image from each of the plurality of sequential x-ray images to generate a plurality of sequential x-ray difference images, filtering of each of the plurality of sequential x-ray difference images based on one or more filter parameters to generate a plurality of sequential filtered x-ray difference images, combination of each of the plurality of sequential filtered x-ray difference images with a corresponding one of the plurality of sequential x-ray difference images based on a weight to generate a plurality of combined sequential x-ray images, and display of the plurality of combined sequential x-ray images sequentially.