Face masks that can be used, for example, in medical and surgical procedures, including both completely or partially disposable and reusable masks, that can be custom fitted to the wearer, and which can include one or more filtering inhalation and exhalation valves and/or compartments allowing for separated filtering of inhalation and exhalation gases. Some embodiments include systems, methods and kits for reducing contaminants in an inhalation and exhalation flow stream.