Invention Grant
US09321746B2 Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
有权
苯并噻吩衍生物及其组合物作为选择性雌激素受体降解物
- Patent Title: Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
- Patent Title (中): 苯并噻吩衍生物及其组合物作为选择性雌激素受体降解物
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Application No.: US14768341Application Date: 2014-02-12
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Publication No.: US09321746B2Publication Date: 2016-04-26
- Inventor: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- International Application: PCT/US2014/015938 WO 20140212
- International Announcement: WO2014/130310 WO 20140828
- Main IPC: A61K31/00
- IPC: A61K31/00 ; C07D333/64 ; A61K31/381 ; A61K31/4196 ; A61K31/422 ; A61K31/4245 ; A61K31/4436 ; A61K31/506 ; A61K45/06 ; C07D333/66 ; C07D409/12 ; C07D413/04 ; C07D413/12 ; C07D409/04 ; C07D409/10 ; C07D417/12 ; A61K31/397 ; A61K31/4025 ; A61K31/404 ; A61K31/41 ; A61K31/428 ; A61K31/5377
Abstract:
The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
Public/Granted literature
- US20150361065A1 BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS Public/Granted day:2015-12-17
Information query
