Invention Grant
- Patent Title: Pyridyl inhibitors of hedgehog signalling
- Patent Title (中): 刺猬信号的吡啶基抑制剂
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Application No.: US14575018Application Date: 2014-12-18
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Publication No.: US09321761B2Publication Date: 2016-04-26
- Inventor: Janet L. Gunzner-Toste , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F. T. Koehler
- Applicant: GENENTECH, INC. , CURIS, INC.
- Applicant Address: US MA Lexington US CA South San Francisco
- Assignee: CURIS, INC.,GENENTECH, INC.
- Current Assignee: CURIS, INC.,GENENTECH, INC.
- Current Assignee Address: US MA Lexington US CA South San Francisco
- Agency: Millen White Zelano & Branigan, PC
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D417/04 ; C07D417/12 ; C07D213/38 ; C07D213/40 ; C07D213/56 ; C07D213/70 ; C07D213/75 ; C07D213/81 ; C07D213/82 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D409/12 ; C07F9/58
Abstract:
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
Public/Granted literature
- US20150105550A1 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING Public/Granted day:2015-04-16
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