Invention Grant
US09321840B2 Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind CD154 and uses thereof
有权
结合蛋白质，包括特异性结合CD154的抗体，抗体衍生物和抗体片段及其用途
- Patent Title: Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind CD154 and uses thereof
- Patent Title (中): 结合蛋白质，包括特异性结合CD154的抗体，抗体衍生物和抗体片段及其用途
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Application No.: US14309118Application Date: 2014-06-19
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Publication No.: US09321840B2Publication Date: 2016-04-26
- Inventor: Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
- Applicant: UCB PHARMA S.A. , BIOGEN IDEC MA INC.
- Applicant Address: BE Brussels US MA Cambridge
- Assignee: UCB BIOPHARMA SPRL,BIOGEN MA INC.
- Current Assignee: UCB BIOPHARMA SPRL,BIOGEN MA INC.
- Current Assignee Address: BE Brussels US MA Cambridge
- Agency: Saliwanchik, Lloyd & Eisenchenk
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/00
Abstract:
This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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