Invention Grant
US09322041B2 Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans
有权
能够产生β-葡聚糖的转基因微生物和生产β-葡聚糖的方法
- Patent Title: Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans
- Patent Title (中): 能够产生β-葡聚糖的转基因微生物和生产β-葡聚糖的方法
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Application No.: US13935043Application Date: 2013-07-03
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Publication No.: US09322041B2Publication Date: 2016-04-26
- Inventor: Beata Brockmann , Andrea Herold , Oskar Zelder , Stefan Haefner , Christian Fleck , Hartwig Schröder , Mari Granström , Julia Kristiane Schmidt
- Applicant: BASF SE , Wintershall Holding GmbH
- Applicant Address: DE Ludwigshafen DE Kassel
- Assignee: BASF SE,Wintershall Holding GmbH
- Current Assignee: BASF SE,Wintershall Holding GmbH
- Current Assignee Address: DE Ludwigshafen DE Kassel
- Agency: Drinker Biddle & Reath LLP
- Main IPC: C12P19/04
- IPC: C12P19/04 ; C12N15/80 ; C12N9/10 ; C08B37/00 ; C08L5/00

Abstract:
The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.
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