Disclosed are a resource scheduling method, apparatus and base station for reducing the signaling overhead of the downlink control channel instruction in uplink and downlink data transmission. The method comprises: configuring semi-persistent scheduling parameters for a user equipment (UE) when the cell of the UE is determined to be an interference limited cell and a semi-persistent scheduling mechanism needs to be set for the UE; allocating semi-persistent scheduling resources to the UE for transmitting service data according to the semi-persistent scheduling parameters when the UE is determined to be in need of a semi-persistent scheduling mechanism for transmitting the service data of access services; sending the resource scheduling information of the semi-persistent scheduling resources to the UE over the downlink control channel of the UE. The technical solution provided in the present application reduces the signaling overhead of the downlink control channel instruction during data transmission, reduces inter-cell interference of the downlink control channel, and improves the reception capability of the downlink control channel, quality of service (QoS) and cell spectrum efficiency.