Cable structures with insulating tape and systems and methods for making the same are provided. In some embodiments, a cable may include a first group of conductors extending along a length of the cable, a tape wrapped directly around the first plurality of conductors along the length of the cable, and a second group of conductors extending along the length of the cable, where the tape electrically isolates the first group of conductors from the second group of conductors. The second group of conductors may extend around the tape or the tape may be wrapped directly around the second group of conductors. The tape may be a polymeric tape that may or may not include an adhesive.