A multiple image sensor image acquisition system includes a clock control unit to generate a synchronization clock signal. The synchronization clock signal has a prolonged constant cycle during which the synchronization clock signal is held at a constant level for a period of time corresponding to multiple clock cycles. A first image sensor is coupled with the clock control unit to receive the synchronization clock signal and has a first synchronization unit that is operable to synchronize operation for the first image sensor based on detection of an end of the prolonged constant cycle. A second image sensor is coupled with the clock control unit to receive the synchronization clock signal and has a second synchronization unit that is operable to synchronize operation for the second image sensor based on detection of the end of the prolonged constant cycle. The image sensors are synchronized operationally.