Invention Grant
US09333255B2 Methods of enhancing antibody-based antiviral therapies by administering KIR2DL-binding antibodies
有权
通过施用KIR2DL结合抗体来增强基于抗体的抗病毒治疗的方法
- Patent Title: Methods of enhancing antibody-based antiviral therapies by administering KIR2DL-binding antibodies
- Patent Title (中): 通过施用KIR2DL结合抗体来增强基于抗体的抗病毒治疗的方法
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Application No.: US14043402Application Date: 2013-10-01
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Publication No.: US09333255B2Publication Date: 2016-05-10
- Inventor: Peter Andreas Nicolai Reumert Wagtmann , Francois Romagne , Joakim Glamann
- Applicant: Novo Norkisk A/S , Innate Pharma S.A.S.
- Applicant Address: FR Marseilles DK Bagsvaerd
- Assignee: Innate Pharma S.A.S.,Novo Norkisk A/S
- Current Assignee: Innate Pharma S.A.S.,Novo Norkisk A/S
- Current Assignee Address: FR Marseilles DK Bagsvaerd
- Agency: LeClairRyan
- Agent Robin L. Teskin
- Priority: DK200500027 20050106
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/08 ; A61K39/395 ; A61K45/06 ; A61K39/00
Abstract:
Described are methods of treating viral disease using compounds that block inhibitory NK cell receptors, thereby reducing their inhibition of NK cell cytotoxicity in killing infected target cells. In one embodiment, the compound is an antibody binding, for example, one or more of the human KIR2DL1, KIR2DL2, and KIR2DL3 receptors. In another embodiment, the method further comprises administering a therapeutic antibody or fusion protein which binds an antigen expressed on cells infected with the virus.
Public/Granted literature
- US20140023646A1 Compositions and Methods for Treating Viral Infection Public/Granted day:2014-01-23
Information query
