A nebulization structure with a nozzle plate includes a nozzle plate and a driving element. The nozzle plate is composed of a polymer and a support plate, and the support plate includes a plurality of connecting portions and a through hole, and the polymer covers the support plate and has a plurality of penetrating holes corresponding to the through hole. The driving element is coupled to the nozzle plate through the connecting portions for producing a high-frequency vibration wave through a piezoelectric effect after power is supplied and driving the nozzle plate to vibrate and break up the molecular structure of a solution into a mist, so as to achieve the nebulization effect. The nebulization structure can be installed in a nebulization apparatus to achieve a high-efficiency nebulization effect by the nozzle plate and the driving element, so as to facilitate the manufacturing process and save costs.