Invention Grant
- Patent Title: Pharmacologically active compounds
- Patent Title (中): 药理活性化合物
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Application No.: US14426574Application Date: 2013-09-09
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Publication No.: US09334286B2Publication Date: 2016-05-10
- Inventor: Swen Hoelder , Julian Blagg , Kwai-Ming J. Cheung , Butrus Atrash , Peter Sheldrake
- Applicant: Cancer Research Technology Limited
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Foley Hoag LLP
- Agent David P. Halstead
- Priority: GB1216018.0 20120907
- International Application: PCT/GB2013/052361 WO 20130909
- International Announcement: WO2014/037751 WO 20140313
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D471/04 ; C07D487/04 ; C07D401/14 ; C07D405/14 ; A61K31/4375 ; A61K31/472 ; A61K31/496 ; A61K31/4985 ; C07D491/107 ; C07D413/14 ; C07D401/04 ; C07D401/12
Abstract:
The present invention relates to compounds of formula II wherein X, Y, R2, R3, R4 and Ar are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
Public/Granted literature
- US20150218181A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS Public/Granted day:2015-08-06
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