发明授权
- 专利标题： Pharmacologically active compounds
- 专利标题（中）： 药理活性化合物
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申请号： US14426574申请日： 2013-09-09
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公开(公告)号： US09334286B2公开(公告)日： 2016-05-10
- 发明人: Swen Hoelder , Julian Blagg , Kwai-Ming J. Cheung , Butrus Atrash , Peter Sheldrake
- 申请人： Cancer Research Technology Limited
- 申请人地址： GB London
- 专利权人： Cancer Research Technology Limited
- 当前专利权人： Cancer Research Technology Limited
- 当前专利权人地址： GB London
- 代理机构： Foley Hoag LLP
- 代理商 David P. Halstead
- 优先权： GB1216018.0 20120907
- 国际申请： PCT/GB2013/052361 WO 20130909
- 国际公布： WO2014/037751 WO 20140313
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D471/04 ; C07D487/04 ; C07D401/14 ; C07D405/14 ; A61K31/4375 ; A61K31/472 ; A61K31/496 ; A61K31/4985 ; C07D491/107 ; C07D413/14 ; C07D401/04 ; C07D401/12
摘要：
The present invention relates to compounds of formula II wherein X, Y, R2, R3, R4 and Ar are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
公开/授权文献
- US20150218181A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS 公开/授权日：2015-08-06
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