A system for hybrid self-interference cancellation includes a transmit coupler that samples an RF transmit signal, a RF self-interference canceller that transforms the sampled RF transmit signal to an RF self-interference cancellation signal, an IF self-interference canceller that transforms a downconverted version of the RF transmit signal to an ISRF self-interference cancellation signal, and a receive coupler that combines the RF and ISRF self-interference cancellation signals with an RF receive signal.