The present disclosure proposes a method of cooperative MIMO wireless communication, and a base station using the same. A base station would have a plurality of radio remote units (RRUs), and each of the RRUs may have a specific radio coverage and a plurality of antennas coupled to each of the RRUs. The function of the base station may include receiving a UE information, receiving a service flow, deriving a service type of the service flow, and determining a MIMO scheme, modulating the service flow into a MIMO stream according to the MIMO scheme, allocating a plurality of resource blocks, wherein the resource blocks may correspond to a portion or all of the RRUs, distributing the MIMO stream into a plurality of downlink sub streams and transmitting the downlink sub streams through the resource blocks by the RRUs corresponding to the resource blocks.