A cylinder control method includes: generating a torque request for an engine based on at least one driver input; based on the torque request, determining a target number of activated cylinders of the engine; determining possible sequences for activating and deactivating cylinders of the engine to achieve the target number of activated cylinders; determining predicted fuel consumption values for the possible sequences, respectively; identifying first ones of the possible sequences having predicted fuel consumption values that are less than a predetermined amount from a lowest one of the predicted fuel consumption values; selecting one of the first ones of the possible sequences; setting a selected sequence for activating and deactivating cylinders of the engine to the selected one of the first ones of the possible sequences; based on the selected sequence, one of activating and deactivating a next cylinder in a predetermined firing order of the cylinders.