A thermoelectric refrigeration system including at least one cooling chamber and a thermoelectric heat exchange system. The thermoelectric heat exchange system includes cascaded heat sinks. The cascaded heat sinks include cascaded cold side heat sinks and a hot side heat sink. The cascaded cold side heat sinks include a first cold side heat sink and a second cold side heat sink. The thermoelectric heat exchange system also includes a first plurality of thermoelectric coolers disposed between the first cold side heat sink and the second cold side heat sink and a second plurality of thermoelectric coolers disposed between the second cold side heat sink and the hot side heat sink. Each thermoelectric cooler is a module including multiple thermoelectric devices.